 Years after the Raccoon City disaster, Alice (MILLA JOVOVICH) is on her own knowing that she has become a liability and could endanger those around her is struggling to survive and bring down the Umbrella Corporation lead by the sinister Albert Wesker (JASON O MARA) and head researcher Dr. Issacs (IAN GLEN). Meanwhile traveling through the Nevada Desert and through the ruins of Las Vegas Carlos Olivera, (ODED FEHR) L.J., (MIKE EPPS) and new survivors K-Mart, (SPENCER LOCKE) Claire Redfield,(ALI LARTER) and Nurse Betty (ASHANTI) must fight to survive extinction against hoards of zombies, killer crows and the most terrifying creatures created as a result of the deadly T-Virus that has killed millions.