 This film ends together starting with two different missions. Eva Rojas (Penélope Cruz), a doctor from WHO searches for the source of Plague out broken in some African countries. On the other hand Dirk Pitt (Matthew McConaughey) with his colleagues from NUMA (National Underwater and Marine Agency) are in a mission to discover a battleship drown some where under the Sahara desert. But as time passes they all are found to be fighting against a dictator operating a solar powered waste disposal plant near the Niger River. To save themselves and thus the people of the surroundings they dare to do what they never did!