 After terrorists release a mysterious virus on a small village killing all of its inhabitants, the President of the United States (Harry Hamlin) charges a team of scientists, led by Dr. Galen Bronty (Nastassja Kinski), to find a cure before the plague wipes out all humanity. He then goes into quarantine on a northwestern island to govern the country from a safe zone. But when a terrorist storms the island in a jumbo jet full of children, it s up to the President to somehow stop the spread of the plague before it s too late.