 A woman in an upscale department store gets bitten by a rat. Unfortunately this isn t an ordinary rat and he is not alone. The rats invade the department store and a rec center and that is just the beginning. Soon people across midtown are checking into the hospital with the rare Weil s disease, a disease carried by rats. The health department is too busy covering up the situation to see how widespead and dangerous the infestation really is. Solving the rat problem thus falls to Susan Costello the department store manager, and Jack Carver the suave and discrete exterminator.