 A set of grisly murders brings FBI Agent Will Graham (Norton) out of retirement and puts him in search of an atrocious killer (Fiennes) who s driven by the image of a painting. Yet his only means of survival and success are to seek the help of another madman, whom he himself captured, Dr. Hannibal Lecter (Hopkins). Marked by past scars and quickly running out of time, Graham finds himself tangled in a heap of madness, sacrificing his work, his family, and above all his own life, to put an end to pure evil.