 A rookie FBI agent, Jo Dee Foster ( Billy Zane (qv)), has been assigned to work on the case of the Psycho Killer, a killer who has killed over 120 people. But to find out more about the Psycho Killer, Jo is forced to meet Dr. Animal Cannibal Pizza ( Dom DeLuise (qv)), a famous doctor turned cannibal who ate pizzas with human body parts. Meanwhile, Jo s girlfriend, Jane Wine ( Charlene Tilton (qv)), has just stolen $400,000 in cash from her money-hungry boss, Mr. Laurel ( Rip Taylor (qv)), so she and Jo can be happy, but gets lost in a really horrible storm, caused mostly by a special effects crew behind her car, and stops at the Cemetery Motel, where the owner, Antonio Motel ( Ezio Greggio (qv)), is dominated by his insane mother ( Shelly Winters (qv)).