 In Spain, the former sailor Ramón Sampedro (Javier Bardem) has been quadriplegic for twenty-eight years and is fighting in court for his right of practicing euthanasia through an association that defends the freedom of choice and leaded by his friend Géne (Clara Segura). Ramón is introduced to the lawyer that is defending his cause, Julia (Belén Rueda), who has a degenerative fatal disease; and meets Rosa (Lola Dueñas), a lonely worker that has been abused by men. Their relationship changes the behavior and viewpoint of life of Rosa and Julia.