 Cleo, a research chemist, accidentally creates a substance that turns Jacqueline, her boss, into a bi-polar bondage fiend - first, she ropes and gags the astonished Cleo, then begs submissively to be tied and silenced then becomes a raging dominatrix again. Cleo s efforts to find an antidote are curtailed when animal rights terrorists attack the researchers  laboratory and leave the hapless scientists in a desperate predicament.