 Sheena s white parents are killed while on Safari. She is raised by the mystical witch woman of an African tribe. When her foster mother is framed for the murder of a political leader, Sheena and a newsman, Vic Casey are forced to flee while pursued by the mercenaries hired by the real killer, who hopes to assume power. Sheena s ability to talk to the animals and knowledge of jungle lore give them a chance against the high tech weapons of the mercenaries.