 Gwen, Connie, Fran, and Wanda are best friends, high on life. Well, not Wanda. She s the least beautiful one, with the least interesting personality, who s lost her job, and who s always getting dumped by men. But then she meets Duane, the most wonderful man in the world, and he s madly in love with her. He s handsome, successful etc. The other girls don t get it. And then things get weird. Somehow, Duane s attraction to Wanda has thrown the whole world off-track. Can they end their friend s relationship with Mr. Wonderful before it s too late?