 Dr. John Dolittle has the world in his hands: A beautiful wife at his side, two adorable daughters and a career that could not go better. One night, he nearly runs over a dog with his car. The dog yells "bonehead" and disappears. From then on, his childhood ability is back: To communicate with animals. Unfortunately, the word of Dolittle s ability is spreading quickly. Soon, many animals from rat to horse flock to his place to get medical advice. But his colleagues suspect he s going mad, and as the clinic Dolittle used to work for is about to being taken over for a huge amount of money, many decisions have to be made. Believe him? Put him into a mental institution? Sell the clinic? But also his family is close to breaking apart. Until a circus tiger falls seriously ill.