 Detective Carson O Conner (Parker Poisey) and her partner Detective Michael Sloane (Adam Goldberg) are investigating murders of a serial-killer that mutilates and removes the internal organs of the victims. When they meet the mysterious and macabre Deucalion (Vincent Perez), they are informed that Dr. Frankenstein is alive with a legion of followers, using the name of Dr. Victor Helios (Thomas Kretschmann).