 Jesse (Ashton Kutcher) and Chester (Seann William Scott) are two potheads who got so wasted the night before, they don t remember a thing! All they know is Jesse s car is gone and they encounter a transsexual stripper who wants his/her suitcase of stolen money, a group of alien-seeking nerds and an angry street gang. And their girlfriends Wilma & Wanda (Marla Sokoloff & Jennifer Garner) are super-pissed that they trashed their house. And they must find a "continum transfuctioner", a mystical device that could either save or destroy the world. And a group of jumpsuit-wearing, sexy-as-hell, aliens posing as humans want it....