 Quantum Airlines flight 66 has just taken off from Frankfurt, Germany bound for New York s JFK International Airport with 247 passengers aboard. After take-off, a man infected with a Doomsday Virus passes out while a flight attendant and doctor try to save the man. The pilot tries to land the plane but can t because the people on the ground know about the virus. An ambassador and his secretary help the pilot struggle through the government s secret attempt to shoot flight 66 out of the air. And if the plane does land, Doomsday has arrived on earth.