 Mrs. Van Houten has shown signs of losing touch with reality, and her husband discusses possible treatment with Dr. Caligari, who says Mrs. Van Houten has a disease of the libido. The staff want Dr. Caligari removed from their facility due to her controversial experiments with electroshock and hypothalamus injections. As Dr. Caligari continues experimenting with her patients, her daughter and son-in-law attempt to stop her.