 World-renowned physicist Dr. Jack Murray and his lab partner Hank are experimenting with fifth-dimension time travel when they suddenly disappear without a trace. Several months after this mysterious event, Dr. Murray s children - the loving but youthfully awkward Meg and the gifted, eccentric Charles Wallace - have still had no news of their father. Then, quite suddenly, they and their neighbour Calvin O Keefe are summoned by strange, mystical forces to find the missing physicist. Thus the three embark on a perilous quest to other worlds to find Hank and Dr. Murray. Guided by three celestial beings - Mrs. Whatsit, Mrs. Who and Mrs. Which - the travellers must survive a myriad of dangers before the children can reunite their family. Part fantasy, part coming-of-age.