 Five years ago, Carl Johnson escaped Los Santos after the death of his brother Brian. Now, he returns to find his mother dead, and his childhood friends in a rut. The Ballas have taken over Grove Street territory and drug dealers are selling everywhere. On his return to the city, officers Frank Tenpenny and Eddie Pulaski frame Carl for homicide and steal his money. Carl sees what his home has become, he needs to repair the damage done and take control of the streets.