 Male nurse Greg Focker (Ben Stiller) is poised to propose to his girlfriend Pam (Teri Polo) during a weekend stay at her parents  home. But here s the catch . . . he needs to ask her father first. Alas, the fur flies as Jack Byrnes, Pam s cat-crazy, ex-CIA father, played by Robert De Niro, takes an immediate dislike to her less-than-truthful beau. Greg s quest for approval gets seriously sidetracked as Murphy s Law takes over and a string of mishaps turns him into a master of disaster and total pariah in the eyes of the entire family . . . all except for his shell-shocked girlfriend, who can t believe she still loves her one-man wrecking crew.