 The third movie-video game adaptation brings Spider-Man back to the crime ridden streets of New York City which are more dangerous than ever. Whilst Spider-Man deals with three new gangs (Apocalypse, Dragontail and Arsenic Candy) who have declared war on Manhattan; Peter Parker suffers from a disdainful Harry Osborn, pleasing his girlfriend Mary Jane Watson and competing with an unscrupulous and cocky rival photographer at the Daily Bugle- Eddie Brock Jr. This is just the beginning as matters worsen with Dr. Connors morphing into the hideous Lizard and the powerful yet bittersweet Scorpion flees from an experimental hell. When an alien substance known as symbiote bonds with Spider-Man making him almighty, the dangerous streets are cleansed of crime but at the price of Spider-Man/Peter Parker s metamorphosis into a filthier and malevolent being.