 Presidents Hotel is a slice of life story revolving around a small residential hotel in the Tenderloin District of San Francisco over a single day. Nick, an alcoholic veteran with nothing to live for meets Cassia, a troubled young girl from the "Alley". Lenny, the lonely hotel janitor tries to find love in between his monotonous duties with the residents. Ralan, an ex-con released from prison comes back to town with a vengeance, eager to settle an old score no matter what the cost.