 In the Century XXV, a virus exterminated most of the population of Earth, and the last city is Bregna, which is ruled by Trevor Goodchild (Marton Csokas) and protected by wall from the outside world. The women are sterile, and the population is cloned living many lives. A resistance group entitled Monicans and led by The Handler (Frances McDormand), assigns the assassin Aeon Flux (Charlize Theron) to kill Trevor and overthrow the government. However, Aeon Flux discloses a scheme plotted by Oren Goodchild (Jonny Lee Miller) against his brother Trevor and she resolves to protect Trevor instead of killing him.