 Citizens of San Francisco are stunned by the news that Robert Ironside, the city s hard-nosed, tough-talking chief of detectives, has been shot and left for dead while vacationing at his friend the Police Commissioner s rural retreat. Ironside survives the murder attempt, but the bullet has damaged nerves in his spine, leaving him a paraplegic. Unable to gain reinstatement as chief of detectives, Ironside gets permission to continue investigating criminal cases as a citizen volunteer. With the assistance of two former protegees, Det. Sgt. Ed Brown and Officer Eve Whitfield, and a newly-hired aide/driver, Mark Sanger, Ironside sets out to solve his first case as a civilian by finding the people responsible for the attempt on his life.