 Ham III (Samberg), the grandson of the first chimp astronaut, is blasted off into space by an opportunity-seeking senator (Tucci). Soon, the fun-loving chimp has to get serious about the mission at hand: Rid a far-away planet of their nefarious leader (Daniels). Fortunately for Ham III, two of his simian peers (Hines and Warburton) are along for the ride.