 Mamie Toll (Lisa Kudrow) is an abortion clinic counselor with a massage therapist lover, Javier (Bobby Cannavale), and a secret: when she was younger, she and her gay stepbrother, Charley Peppitone (Steve Coogan), had a child she gave up for adoption. One day, Nicky Kunitz (Jesse Bradford), a sleazy filmmaker, shows up and plans to blackmail her with information on her child s whereabouts so that he can film the reunion and use it to get into the AFI. Charley now runs his father s restaurant with his lover, Gil (David Sutcliffe), and suspects that their lesbian friends, Pam (Laura Dern) and Diane (Sarah Clarke), lied about using Gil s sperm to create a child so that they wouldn t have to share him with them. Jude (Maggie Gyllenhaal) has been kicked out of her cousin s house and is now living with the latent Otis (Jason Ritter), who lives with his widower father, Frank McKee (Tom Arnold), who has become infatuated with Jude. What Jude didn t count on was actually falling in love with Frank. In the end, will anyone have a happy ending?