 Two years have passed for Peter Parker, established in his role as college student...and as a crimefighter. He can t keep up at school, pay his rent or make amends with his estranged best friend Harry, who wants Spider-Man dead. Mary Jane is more skeptical than ever of the man in her life. Peter s idol, a renowned scientist named Otto Octavius, resurfaces following a failed fusion experiment. Peter, at times noticing he s losing some of his powers, and is feeling the effects of the stress in his personal life, realizes he must decide between being who he once was or retaining his secret identity to stop "Doc Ock" and save New York City.