 Marina, Adán, Mimí, and Ignacio met in high school. Marina and Adan were best friends; they shared secrets, chewing gum, and even pajamas. One of Marina s biggest secrets was that she was madly in love with Ignacio, but he barely noticed she was alive. Meanwhile, Adan bullied and picked on Mimi nearly every single day, and it drove her crazy. Twelve years later, the four meet again at their high school reunion, with some of the same old baggage, doubts, and questions that haunted them then, and some new ones, that come with being on the verge of turning 30: Who am I? What should I do with my life? Who do I want to spend the rest of my life with? What ever happened to that old flame? How did ever I get so screwed up, and whose fault is it? Instead of answers, the four find revenge, romance, chases, love songs in the middle of the night (and of the street), hit and run accidents, collapsing buildings, vodka, foreplay, flight attendants, psycho bees, Cheetos, Twinkies, butterflies, true love, sheep, the greatest kiss in the world, and a dead cat. And the four also find, by the end of this dark comedy, that everything in life has Side Effects.