 In Chicago, the former photographer and presently advertising executive Mathew (Josh Hartnett) is closing a business deal in a fancy restaurant with a Chinese representative, when he sees a woman that looks like his former passion Lisa (Diane Kruger). Two years ago, Lisa and Matthew had a love affair, and Lisa simply vanished when Matthew invited her to move with him to New York, where he had the invitation for a better job, and Matthew is still obsessed for her. Matthew decides to follow Lisa, and when he meets her, he realizes that Lisa is indeed another woman (Rose Byrne) with the same name. Matthew stays in Chicago with his friend Luke (Matthew Lillard) and decides to investigate the mystery.