 Myron Breckinridge is waiting for his sex-change operation while a stoned surgeon stumbles into the operating room. Before the drugged doctor begins Myron s operation, he counsels him. Myron persists and the doctor goes through with it. An enthusiastic audience observing the operation applauds the medical achievement and rises in a standing ovation. After the operation, Myron arrives in Hollywood as Myra while in the rest of the film Myron pops up from time to time as Myra s alter ego. Myra goes to an acting academy owned by her uncle, Buck Loner, a former cowboy star. The real reason for Myra s arrival is to claim her half of Uncle Buck s estate, which she says she s entitled to. Buck Loner stalls by giving her a job teaching the history of motion pictures. Buck Loner has several friends. One of them is Letitia Van Allen, an ancient Hollywood talent scout. The sex-starved septuagenarian runs an acting agency "for leading men only."