 Siblings Darryl (Justin Long) and Trish (Gina Phillips) are on their way home from their freshman year at college. But the trip starts turning dangerous as they see a man in a trench coat and a hat that covers his face dumping something down a pipe. They recognize him as the man who tried to run them off the road earlier and go see what he dumped after he leaves, but what they discover is too terrifying for them. They get help from a crazy woman who has too many cats (Eileen Brennan) and a psychic (Patricia Belcher) before they realize what s been chasing them is an ancient demon known as the Creeper (Jonathan Breck) who eats people to regenerate his parts and he sees something in one of them that he wants for his snack.