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UID:calendar.18977.field_data.0@diag.uniroma1.it
DTSTAMP:20260404T173422Z
CREATED:20200117T145524Z
DESCRIPTION:In ottemperanza ai requisiti previsti dalla procedura selettiva
  per n.1 posto di professore di ruolo di II fascia SC 09/G2 SSD ING-INF/06
  - Dipartimento di Ingegneria Informatica Automatica e Gestionale 'A. Rube
 rti'\, Codice bando: 2018PAE018\, giovedì 23 gennaio 2020\, alle ore 12:30
 \, in aula A6 si terrà il seminario di Paola Paci che illustrerà sue attiv
 ità di ricerca svolte e in corso di svolgimento. Successivamente al semina
 rio\, alle ore 13:30\, nella stessa aula\, Paola Paci terrà una lezione il
  cui titolo verrà estratto il giorno 22 gennaio\, alle ore 12:00 presso la
  Direzione del Dipartimento in presenza della direttrice prof.ssa Tiziana 
 Catarci. 
DTSTART;TZID=Europe/Paris:20200123T123000
DTEND;TZID=Europe/Paris:20200123T123000
LAST-MODIFIED:20210425T095559Z
LOCATION:A6 DIAG
SUMMARY:Public Seminar - \n\n\n  \n  \n\n    \n\n\nPaola\n\n\nPaci  \n\n  
 \n\n    \n\n\n\n\n\nProfessore associato\n\nstanza: \n\nA106\n\ntelefono: 
 \n\n+39 0677274088\n\nMember of: \n\n  \n\n  \n\n    \n\nBiografia: \n\n\n
 \n \n\n\nPersonal Information\n\n\nPaola Paci\n\n\nORCID: 0000-0002-9393-2
 047\n\n\nDate of birth: 04/11/1972\n\n\nNationality: Italian\n\n\n \n\n\nE
 ducation\n\n\n2010 - Second Level Master in Bioinformatics at Sapienza Uni
 versity of Rome\, Italy\n\n\n2003 - PhD in Physics at the University of Pa
 via\, Italy\n\n\n1999 - MSc in Physics at Sapienza University of Rome\, It
 aly\n\n\n \n\n\nCurrent Position\n\n\n2020-present: Associate Professor at
  the Department of Computer\, Control\, and Management Engineering 'Antoni
 o Ruberti' of Sapienza University of Rome\n\n\n2022-present: Affiliate Pro
 fessor at the Department of Laboratory Medicine\, Cardio-Metabolic Unit of
  Karolinska Institutet\, Stockholm\, Sweden\n\n\n \n\n\nPrevious Positions
 \n\n\n2022-2023: Visiting Professor at Brigham and Women's Hospital of Har
 vard Medical School\, Boston\, MA (US)\n\n\n2011-2020: Researcher at the I
 nstitute for Systems Analysis and Computer Science (IASI) 'Antonio Ruberti
 '\, CNR\, Rome\, Italy\n\n\n \n\n\nFellowships and awards\n\n\n2018: Best 
 Poster Awards\, Bioinformatics Italian Society (BITS)\n\n\n2017: Best Post
 er Award (700 USD)\, IEEE Technical Committee on Computational Life Scienc
 e Society (TCCLS)\n\n\n2016: Best Poster Award (500 USD)\, IEEE Technical 
 Committee on Computational Life Science Society (TCCLS)\n\n\n2014: SysBio 
 award (10.000 euro)\, SYSBIO – Centre of Systems Biology\n\n\n2010: Second
  Level Master award (1500 euro)\, Sapienza University of Rome\, Italy\n\n
 \n \n\n\nSupervision of graduate students\; PhD PostDoc students\n\n\n \n
 \n\nSapienza University of Rome\, Italy:\n\n\n2011-present: 17 MCs graduat
 ing students in Biomedical Engineering\, 3 MSc in Genetics and Molecular B
 iology\, 1 MSc in Computer Science\, 2 MSc in Management Engineering\, 13 
 BSc in Bioinformatics\, 1 BSc in Biological Science\n\n\n2012-2015: 1 PhD 
 student in Engineering in Computer Science\n\n\n2019-present: 3 PhD studen
 ts in 'Innovative Biomedical Technologies in Clinical Medicine'\n\n\n2021-
 2023: 2 PostDoc students\n\n\n2022-2015: 3 Post-graduate fellowships\n\n\n
 2021-2026: 1 fixed-term research position (RTDA )\n\n\n \n\n\nCampus Biome
 dico University of Rome\, Italy:\n\n\n2009-2012: 5 BSc and 1MSc graduating
  students in Biomedical Engineering\n\n\n \n\n\nIASI-CNR of Rome\, Italy:
 \n\n\n2015-2021: 4 PostDoc students\n\n\n \n\n\nTeaching activities\n\n\n 
 \n\n\nProfessor at Sapienza University of Rome for:\n\n\n2020-present: Bio
 informatics II\, BSc Bioinformatics\, Faculty of: Pharmacy and Medicine\; 
 Information Engineering\, Informatics and Statistics\; Medicine and Dentis
 try\; Mathematical Physical and Natural Sciences\n\n\n2014-present: Bioeng
 ineering for Genomics\, MSc in Biomedical Engineering\, Faculty of Civil a
 nd Industrial Engineering Bioinformatics\n\n\n2015-2017: Computational Bio
 logy\, MSc in Genetics and Molecular Biology\, Faculty of Mathematical Phy
 sical and Natural Sciences\n\n\n \n\n\nAdjunct Professor at Campus Biomedi
 co University of Rome for:\n\n\n2012-2014: Applied Genomics\, MSc Food Sci
 ence and Human Nutrition\, Departmental Faculty of Medicine and Surgery\n
 \n\n2007-2011: Calculus\, BSc Biomedical Engineering\, Faculty of Engineer
 ing\n\n\n2008-2012: Mathematical Methods\, BSc Biomedical Engineering\, Fa
 culty of Engineering\n\n\n \n\n\nOrganisation of scientific meetings\n\n\n
 2025: Organizer and Co-Director of the 3-day Workshop “The Network Medicin
 e Training Course”\, organized by Sapienza University of Rome and Brigham 
 and Women's Hospital\, Harvard Medical School.\n\n\n2024: Organizer and Pr
 ogram Co-chair of 'The 2nd Workshop on Challenges and Opportunities in Net
 work Medicine and Multi-Omics bioinformatics’ approaches for studying huma
 n complex diseases'\, held in conjunction with IEEE International Conferen
 ce on Bioinformatics and Biomedicine (BIBM 2024)\, Lisboa (Portugal).\n\n
 \n2023: Organizer and Program Co-chair of the “Workshop on Challenges and 
 Opportunities in Network Medicine and Multi-Omics bioinformatics’ approach
 es for studying human complex diseases'\, held in conjunction with IEEE In
 ternational Conference on Bioinformatics and Biomedicine (BIBM 2023)\, Ist
 anbul (Turkey).\n\n\n \n\n\nInstitutional responsibilities\n\n\n2018-prese
 nt: Member of the board of the PhD program in 'Innovative Biomedical Techn
 ologies in Clinical Medicine'\, Department of Translational and Precision 
 Medicine\, Sapienza University of Rome\, Italy.\n\n\n2020-present: Member 
 of the Quality Assurance Management Commission (CGAQ) of the Course of Stu
 dy in Biomedical Engineering\, Faculty of Civil and Industrial Engineering
 \, Sapienza University of Rome\, Italy.\n\n\n2024-present: Vice-President 
 of the Bachelor’s Program in Bioinformatics of Sapienza University of Rome
 .\n\n\n2024: Director of the Advanced Training Course (CAF) in “Network Me
 dicine: una nova visione della medicina”\, organized by Sapienza Universit
 y of Rome and Confindustria Dispositivi Medici.\n\n\n2024: Member of the S
 cientific Teaching Committee of the Second Level Master in 'Gestione integ
 rata dei dispositivi medici-medical technologies regulatory affairs'\, org
 anized by Sapienza and Confindustria Dispositivi Medici.\n\n\n2023: Member
  of the Scientific Teaching Committee of the Advanced Training Course (CAF
 ) in “Advanced Bioinformatics Technologies”\, organized by Fondazione Goli
 nelli\, Innovation-Culture.\n\n\n2015-2017: Member of the board of the PhD
  program in 'Life Science and Biology and Biotechnology'\, Bicocca Univers
 ity of Milan\, Italy.\n\n\n \n\n\nReviewing and editorial activities\n\n\n
 2018-present: Editorial Board Member of Scientific Reports\, Nature\n\n\n2
 022-present: Associate Editor of Biotechnology Reports\, Elsevier\n\n\n \n
 \n\nMemberships of scientific societies\n\n\n2022-present: member of\n\n\n
 - Steering and Scientific Committee of the Network Medicine Institute and 
 Global Alliance\n\n\n- GNB - Gruppo Nazionale di Bioingegneria\n\n\n \n\n
 \nMajor collaborations\n\n\nJ. Loscalzo\, E. Silverman\, Network Medicine\
 , Brigham and Women’s Hospital\, Harvard Medical School\, Boston\, MA (USA
 )\n\n\nP. Parini\, Network Medicine\, Karolinska Institutet\, Stoccolma\n
 \n\nI. Caruana\,  ‪Immunotherapy\, University Children's Hospital of Würzb
 urg\n\n\nE. Ferretti\, V. Panebianco\, Radiomics\, Policlinico Umberto 1\,
  Rome\, Italy\n\n\nT. Manzo\, Oncology\, European Institute of Oncology (I
 EO)\, Milan\, Italy\n\n\nInteressi di ricerca: \n\n\n\nComputaitonal Biolo
 gy and Bioinformatics\n\n\nMy research focuses on developing algorithms to
  identify potential biomarkers and therapeutic interventions\, including d
 rug repurposing\, within the framework of Network Medicine. This emerging 
 field has been dramatically changing the way we define human diseases: fro
 m isolated entities to interconnected molecular processes. Notable algorit
 hms I’ve developed in last 10 years include:\n\n\n1.     SWIM (SWItch Mine
 r)\, a network-based tool for identifying potential biomarkers [1\,4\,6\,7
 \,9\,10]. This methodology has gained widespread recognition within the sc
 ientific community thanks to the encouraging results achieved when applied
  to glioblastoma [9]\, leading to the identification of FOSL1 as a possibl
 e biomarker\, which promotes the differentiation of cancer stem-like cells
  by repressing key transcription factors responsible for the stem-like phe
 notype. These findings have been experimentally validated [doi.org/10.1038
 /s41598-021-94072-0]\n\n\n2.     SPINNAKER (SPongeINteractionNetworkmAKER)
 \, a network-based tool for identifying putative competing endogenous RNA 
 (ceRNA) interactions [2]. This methodology has aroused a broad acknowledge
 ment within the scientific community thanks to the encouraging results ach
 ieved when applied to breast invasive carcinoma\, leading to the identific
 ation of PVT1\, a long non-coding RNA functioning as ceRNA for the miR-200
  family.\n\n\n3.     SAveRUNNER (Searching off-lAbel dRUg aNd NEtwoRk)\, a
  network-based algorithm for drug repurposing [5] and side-effect estimati
 on [3]. This methodology has been highly successful and well-received by t
 he international scientific community thanks to the encouraging results ac
 hieved when applied to COVID-19\, leading to the identification of a list 
 of repurposable drugs including some of the most rumoured off-label drugs\
 , like: ACE-inhibitors\, monoclonal antibodies (e.g.\, anti-IFNγ\, anti-TN
 Fα\, anti-IL12\, anti-IL1β\, anti-IL6)\, and thrombin inhibitors.\n\n\n4. 
     MIENTURNET (MicroRNA ENrichment TURned NETwork) is an easy-to-use web 
 tool that tackles the problem of prioritizing miRNA-target interactions by
  performing a statistical analysis followed by a fully featured network-ba
 sed visualization and analysis [8]. This tool\, essential for understandin
 g miRNA regulatory mechanisms\, has been widely adopted\, with over 200 ci
 tations (in SCOPUS) since 2019.\n\n\nkeywords: \n\nBioengineering for Mole
 cular Biology and Bioinformatics\n\nqualifica_rr: \n\nAssociate professors
URL;TYPE=URI:http://diag.uniroma1.it/node/18977
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