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2018, PHYTOCHEMISTRY REVIEWS, Pages 291-326 (volume: 17)

BacHBerry: BACterial Hosts for production of Bioactive phenolics from bERRY fruits (01a Articolo in rivista)

Dudnik Alexey, Almeida A. Filipa, Andrade Ricardo, Avila Barbara, Bañados Pilar, Barbay Diane, Bassard Jean-Etienne, Benkoulouche Mounir, Bott Michael, Braga Adelaide, Breitel Dario, Brennan Rex, Bulteau Laurent, Chanforan Celine, Costa Inês, Costa Rafael S., Doostmohammadi Mahdi, Faria Nuno, Feng Chengyong, Fernandes Armando, Ferreira Patricia, Ferro Roberto, Foito Alexandre, Freitag Sabine, Garcia Gonçalo, Gaspar Paula, Godinho-Pereira Joana, Hamberger Björn, Hartmann András, Heider Harald, Jardim Carolina, Julien-Laferriere Alice, Kallscheuer Nicolai, Kerbe Wolfgang, Kuipers Oscar P., Shanshan Li, Love Nicola, Marchetti-Spaccamela Alberto, Marienhagen Jan, Martin Cathie, Mary Arnaud, Mazurek Vincent, Meinhart Camillo, Sevillano David Méndez, Menezes Regina, Naesby Michael, Nørholm Morten H. H., Okkels Finn T., Oliveira Joana, Ottens Marcel, Parrot Delphine, Pei Lei, Rocha Isabel, Rosado-Ramos Rita, Rousseau Caroline, Sagot Marie-France, dos Santos Claudia Nunes, Schmidt Markus, Shelenga Tatiana, Shepherd Louise, Silva Ana Rita, da Silva Marcelo Henriques, Simon Olivier, Stahlhut Steen Gustav, Solopova Ana, Sorokin Artem, Stewart Derek, Stougie Leen, Shang Su, Thole Vera, Tikhonova Olga, Trick Martin, Vain Philippe, Veríssimo André, Vila-Santa Ana, Vinga Susana, Vogt Michael, Wang Liangsheng, Wang Lijin, Wei Wei, Youssef Sandra, Neves Ana Rute, Forster Jochen

BACterial Hosts for production of Bioactive phenolics from bERRY fruits (BacHBerry) was a 3-year project funded by the Seventh Framework Programme (FP7) of the European Union that ran between November 2013 and October 2016. The overall aim of the project was to establish a sustainable and economically-feasible strategy for the production of novel high-value phenolic compounds isolated from berry fruits using bacterial platforms. The project aimed at covering all stages of the discovery and pre-commercialization process, including berry collection, screening and characterization of their bioactive components, identification and functional characterization of the corresponding biosynthetic pathways, and construction of Gram-positive bacterial cell factories producing phenolic compounds. Further activities included optimization of polyphenol extraction methods from bacterial cultures, scale-up of production by fermentation up to pilot scale, as well as societal and economic analyses of the processes. This review article summarizes some of the key findings obtained throughout the duration of the project.
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