Dipartimento di Ingegneria informatica, automatica e gestionale

An advanced Fuzzy Logic Controller (FLC) that considers all the states of the brain tumor system is designed for the chemotherapy treatment. A Mamdani-type FLC is proposed for dynamically controlling the chemotherapy drug for the tumor system; the chemotherapy treatment of brain tumors requires advanced strategies which mainly depend upon the severity of the tumor. In this work, the advanced FLC designed aims both at determining the amount of chemotherapy to eliminate tumor cells, and at preserving the minimum amount of healthy and immune cells. The controller's performance is verified using MATLAB software based on different control parameters, showing its effectiveness in reducing the tumor cells. It has shown favorable results in terms of steady-state error, rate of convergence, and amount of drug consumed.