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Bioengineering and Bioinformatics

The research activity in this area deals with the applications of the general methodologies of modelling, estimation, signal processing, machine learning and statistics to the study of physiological and biological systems. Researches on biomedical applications have been performed since the early 70’s with regard to biomechanics, prostheses and modelling of cellular growth.

At present, the group is engaged in a multidisciplinary effort, pursuing a wide range of research topics by developing mathematical methods applied to neurophysiology, to the analysis and integration of omics data, and by designing innovative instrumentation for neurorehabilitation. The main research topics are:

  • Modelling and Identification of tumor response to radiations;
  • Analysis and modeling of insulin secretion and glucose metabolism;
  • Estimation of cerebral connectivity in humans by means of structural and functional models and applications;
  • Design and validation of EEG-based Brain-Computer Interfaces for assistive and rehabilitation purposes;
  • Computational modeling and analysis of omics data.

Research goals include: the study of the mechanisms on the basis of insulin secretion and on the insulin resistance; the potential application of the Brain Computer Interface (BCI) techniques in the rehabilitation of stroke patients; the utilization of the neuroengineering tools in the field of the economy/marketing; the optimization of tumor radiotherapy, the development of computational and bioinformatic tools for the analysis of 3.1 Biomedical Engineering 23 omics data in different organisms and diseases, including berry developments in plants and human solid tumors. Laura Astolfi received prestigious honors (Chair of the Technical Committee di IEEE EMBS in Biomedical Signal Processing since 2015, Fellow of the European Alliance for Medical and Biological Engineering Sciences (EAMBES), Member of the 2017-19 Administrative Committee of the IEEE Society of Engineering in Medicine and Biology, EMBS), and editorial activity (Member of the Scientific Board of the International Society for Brain Electromagenetic Topography – ISBET, Theme Chair for the Annual International Conference IEEE EMBC18, Member of the Scientific Board of the IV IEEE Middle East Conference on Biomedical Engineering – MECBME2018, Member of the Scientific Board of the VI Congresso del Gruppo Nazionale di Bioingegneria – GNB2018). Several national and international cooperations are actually active, among which: Dip. di Fisiologia Umana e Farmacologia, Sapienza Università di Roma; Dip. di Biotecnologie Cellulari ed Ematologia, Sapienza Università di Roma; IRCCS Fondazione Santa Lucia (Roma); Istituto di Medicina Interna Università Cattolica - Policlinico A. Gemelli (Roma); Laboratorio di Oncogenesi Molecolare, Istituto Nazionale Tumori Regina Elena (Roma); Istituto di Analisi dei Sistemi e Informatica (IASI) – CNR (Roma); Istituto per le applicazioni del calcolo (IAC) – CNR (Roma); Laboratorio di Genetica Agraria, Dipartimento di Biotecnologie, Università di Verona; Institut del la Santè et de la Recherche Medicale-Unite 870 Faculté e de Medicine Lyon; Conway Institute of Biomolecular and Biomedical Research University College, Dublin; Bariatric and Metabolic Surgery, King’s College, London; Institute of Medical Statistics, Computer Sciences and Documentation, Friedrich Schiller University, Jena, Germany; Functional Brain Mapping Laboratory, University of Geneva, Switzerland; Perceptual Networks Group, University of Fribourg,Switzerland; Computational Cognitive Neuroscience Lab, Indiana University, Bloomington, USA; Dpt. of Biomedical and Electrical Engineering - University of South California (USA); ECE Kansas State University (USA); New Zealand Brain Research Institute, Christchurch, New Zealand.

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